April 29 2021 at 12:19 PM by Samikshya Joshi
THE NEW 'TRIPLE MUTANT VARIANT' OF COVID-19 VIRUS FOUND IN INDIA UPDATE-14
After the discovery of the Indian variant of the coronavirus, which is also known as a double mutant, researchers say that they have found a triple mutant of the virus that may completely change the way we understand the fresh surge of the Covid cases in India. The 'triple mutant variant' or the 'Bengal strain' is a new variant of the Covid-19 virus that has been detected in India. Scientists say that this variant is more infectious and is spreading rapidly. Scientists found two triple-mutant varieties in patient samples in four states: West Bengal, Maharashtra, Delhi, and Chhattisgarh. Researchers in the country have dubbed it the "Bengal strain" and say it has the potential to be even more infectious than the double-mutant variant. This is considered as a deadlier mutant as three COVID variants have merged to form a new variant. The situation is grimmest in comparison with any nation around the globe. The triple mutant variant is reportedly more infectious than other strains. Experts say that the presence of E484K mutation in it is a cause for concern. E484K is a major immune escape variant and is also found in a number of emerging lineages across the world. What is the 'triple mutant variant'? As the name suggests, a 'triple mutant variant' is formed when three mutations of a virus combine to form a new variant. In this case, the three mutations are 1. A deletion and two changes in spike protein 2. Deletion of H146 and Y145 3. Mutation in E484K and D614G in spike protein The 'triple mutant variant' is the second lineage of the SARS-CoV-2 virus to be identified in India. It is also being called 'B.1.618'. Explaining the new strain, Vinod Scaria, a researcher at the New Delhi-based Council of Scientific and Industrial Research's Institute of Genomics and Integrative Biology (CSIR-IGIB), in a Twitter thread said the earliest sequence of this variant was isolated on October 25 last year in samples collected from a patient in West Bengal. While the lineage of this variant is primarily found in India, members of the lineage have also been found in the US, Singapore, Switzerland, and Finland. Will 'triple mutant variant' impact Covid-19 vaccines? Scientists fear that the new variant may have an impact on vaccine efficacy because the new variant has the major mutation, called E484K, that helps it to evade the immune system. This, experts say, can possibly compromise vaccine efficacy. E484K was also found in the Brazilian and South African variants of the virus.
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